Pair Name	Ginsenoside Rg3, Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Up-regulation	Expression	BAX	hsa581
	Up-regulation	Cleavage	CASP3	hsa836
	Down-regulation	Phosphorylation	PDK1	hsa5163
	Up-regulation	Expression	PTEN	hsa5728
In Vitro Model	Hep-G2	Hepatoblastoma	Homo sapiens (Human)	CVCL_0027
	Huh-7	Adult hepatocellular carcinoma	Homo sapiens (Human)	CVCL_0336
In Vivo Model	Huh7 cells (1×10⁶) in 100 μL PBS were injected subcutaneously into the flank of nude mice. Mice (N = 5 of each group) were randomly divided into four groups once the tumor volume reached 0.2 cm*3.
Result	These findings suggest a promising strategy for HCC treatment, which could be performed in a sufficiently frequent manner.

Pair Name	Ginsenoside Rg3, Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Inhibition-->Glycolysis
Gene Regulation	Down-regulation	Expression	AKT1	hsa207
	Down-regulation	Expression	HK2	hsa3099
	Down-regulation	Expression	PIK3CA	hsa5290
In Vitro Model	Hep-G2	Hepatoblastoma	Homo sapiens (Human)	CVCL_0027
	BEL-7404	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_6568
Result	Rg3 has a synergistic effect on the sensitivity of HepG2 and Bel7404 hepatoma cells to SFN, which is related to HK2-mediated glycolysis and the PI3K/Akt signaling pathway.